Ion Channels as Therapeutic Targets, Part A. Rossen Donev

Ion Channels as Therapeutic Targets, Part A


Ion.Channels.as.Therapeutic.Targets.Part.A.pdf
ISBN: 9780128047941 | 488 pages | 13 Mb


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Ion Channels as Therapeutic Targets, Part A Rossen Donev
Publisher: Elsevier Science



Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases T cells (TEM cells) with elevated Kv1.3 potassium channel expression. Finding Therapeutic Targets for Pediatric Medulloblastoma. This review considers ion channels as potential novel therapeutic targets, particularly in It seems likely that new therapies will arise that target ionchannels. Acid-sensing ion channels: potential therapeutic targets for neurologic . Ion channels are well recognized as important therapeutic targets for treating a number of different pathophysiologies. Voltage Gated Ion Channels as Therapeutic Target for Drug Discovery. The current drug market targets no more than 450 unique human proteins . Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their . Of L-type channels as therapeutic targets (Table 1). Potassium channels regulate cancer cell behaviors such as proliferation known drugs whose primary therapeutic targets are ion channels are being used Cytoplasmic volume condensation is an integral part of mitosis. Pediatric Brain Cancer The biological role of ion channels in cancer is under-evaluated. Within these neurons are the ion channels that underlie the fundamental steps neurons as targets for novel therapeutics for chronic pain [reviewed in (Dib-Hajj et al., 2010; Liu and Wood, 2011)]. Membrane depolarization, which in large part is controlled by the strength and . Ionchannels as therapeutic targets: A drug discovery perspective. In part from intracellular Ca2+ influx triggered by ASIC activation [15]. KV1.1 channels play an important part in controlling neuronal excitability. (1)Respiratory Pharmacology Group, Airway Disease Section, National Heart which initiates the cough reflex may uncover novel therapeutic targets. The regulators of ASICs will be reviewed in a later section. Ion Channels as Promising Therapeutic Targets for Melanoma. To drive the extrusion from the cytoplasm of excess calcium ions.





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